Production scale multifermentors
High-throughput, fully automated multifermenter system for small volume production. Completely independent operations in every single reactor. Stainless-steel fermentors with 5, 10 or 15L working volume. Ideal for experimental design, parallel process optimization studies and pilot scale production. Fully automated cleaning-in-place, in-situ sterilization, media feeding, harvest and calibration sequences allow single person operation. Up to 10 individually controlled fermentors with MS Windows PC based SCADA station. FDA/GMP compliant product contact materials, surface finish and qualified cleaning in place procedures. Each bioreactor is instrumented by control of temperature, pH, DO, pressure, programmable stirrer and feed pumps, air and oxygen, gas mass-flow controllers. High performance magnet coupled stirrer for elevated oxygen transfer and high density cultivation. Steam sterilizable connections for media feed, sampling and harvest. Optional integrated on-line instruments: optical biomass, off-gas analyser.
Additional features (software highlights):
Sophisticated gravimetric loop back control of the feed pumps provides regulated feed unaffected by pressure changes or pump-tube deformation. Cascade controllers provide advanced and flexible control of DO by stirrer speed, air-flow, pressure and oxygen supplementation. Customized recipe manager provides easy switchover between optimized parameter sets for different microbial processes. Open database and network connectivity allows seamless connection to high-level supervisory system, LIMS and MES.